As p(Thr217)-Tau is considered a highly specific biomarker of AD in both preclinical and advanced stages of AD in humans (e.g., Fukumoto et al., 2002; Johnson and Stoothoff, 2004), it is tempting to speculate that female hippocampus may telescope through normal aging-related neuropathology. The gene discussed is MAPT; the disease is Alzheimer disease.