Furthermore, in a colonic adenoma double mutant mouse model, loss of adenoma polyposis coli (Apc) and indian hedgehog led to increased epithelial cell proliferation and EREG upregulation in colonic fibroblasts, while recombinant EREG was shown to promote proliferation of Apc mutant colonic organoids [93]. The gene discussed is EREG; the disease is colon adenoma.