The enriched CC terms localized anti‐HCC targets to the cytoplasm, cytosol, plasma membrane, extracellular exosomes, and nucleoplasm, while MF enrichment predominantly involved protein binding, ATP binding, protein serine/threonine/tyrosine kinase activity, protein kinase activity, and protein kinase binding, reinforcing the therapeutic relevance of benzoxazinone derivatives in modulating key MF and cellular processes involved in HCC progression. Here, WEE1 is linked to hepatocellular carcinoma.