c‐Myc, a key transcriptional regulator in HCC, lacks a traditional druggable pocket [61], yet ZAK‐I‐57 effectively interacts with LYS24 and LYS45, suggesting a potential disruption of Myc‐Max dimerization, a critical step for oncogenic transcriptional activation [62]. This evidence concerns the gene MYC and hepatocellular carcinoma.