ABCG2 and Cushing syndrome due to macronodular adrenal hyperplasia: KEGG analysis revealed that the metabolites exhibiting significant differences between the UA and the AMI group were primarily enriched in thermogenesis, biosynthesis of unsaturated fatty acids, cortisol synthesis and secretion, Cushing syndrome, fatty acid biosynthesis, steroid hormone biosynthesis, and ABC transporters (Figure 3C).