TNF and breast carcinoma: Dying tumor cells release ssRNA to activate TLR7 signaling, which leads to increased tumor invasiveness [194]. However, the activation of TLR7 of infiltrating macrophages in breast cancer will reduce the secretion of inhibitory inflammatory factor IL‐10, thus promoting the infiltration of cytotoxic lymphocytes into tumor tissue [195]. Activation of TLR7 signaling in DC cells increases the expression levels of various factors that promote antitumor immune response, including IFN‐γ and TNF‐α [196].