TNF and neoplasm: TLR3 can mediate the maturation and differentiation of DC cells. In TNBC, DC cells recognize tumor components through TLR3 and exert immune surveillance function through DAMP [186]. The activation of TLR3 signaling on macrophages in TNBC tissue can mediate an increase in the secretion of chemokines such as CXCL10, inflammatory cytokines IL‐6, TNF‐α, and promote antitumor immune response [187].