CCDC88B and hypothyroidism: Among the genes identified, CCDC88B and MMEL1 were found to have positive associations with the risk of hypothyroidism (CCDC88B: OR = 1.004, p=4.69E − 07; MMEL1: OR = 1.004, p=6.65E − 06) and FinnGen cohorts (CCDC88B: OR = 1.044; MMEL1: OR = 1.038).