PIK3R1 and familial pancreatic carcinoma: This aligns with our KEGG analysis showing PI3K-AKT pathway enrichment and previous reports of miR-486-5p/PIK3R1 axis in non-small cell lung cancer, pancreatic cancer and diabetic nephropathy (Tian et al., 2019; Kong et al., 2020; Su et al., 2024).