CXCR2 is particularly involved in neutrophil recruitment, tumor progression, and the establishment of a pre-metastatic niche, which makes it a popular target for diseases such as chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, asthma, and cancer (Ha et al., 2017; Cheng et al., 2019). This evidence concerns the gene CXCR2 and chronic obstructive pulmonary disease.