HMGB1 and acute kidney injury: Silencing HMGB1 restores the protective effects of circTLK1 knockdown diminished by the miR-106a-5p inhibition, underscoring the pivotal role of the circTLK1–miR-106a-5p–HMGB1 regulatory axis in sepsis-associated AKI (Xu et al., 2021).