Maslinic acid (MA) (Liou et al., 2019a), Crocin (Luo et al., 2019), and Ursolic acid (UA) (Cheng et al., 2020) all improve hepatic steatosis and treat MAFLD by activating the AMPK pathway, promoting fatty acid oxidation, lipolysis, and inhibiting fat synthesis. The gene discussed is PRKAA1; the disease is fatty liver disease.