Studies by Zhang D et al. have shown that TQ triggers autophagy through the activation of the AMPK/ULK1(Ser555) and AMPK/mTOR/ULK1(Ser757) pathway-dependent mechanisms, thereby reducing body weight, alleviating hepatic steatosis, and improving glucose homeostasis (Zhang D. et al., 2023). The gene discussed is ULK1; the disease is fatty liver disease.