Glycogen Synthase Kinase 3 Beta (GSK3β) expression is elevated in AML-NK cells and GSK3β pharmacological inhibition promotes conjugator formation by up-regulating LFA expression on NK cells and inducing ICAM-1 expression on AML cells, thereby enhancing the cytotoxic activity of AML-NK cells. Here, ICAM1 is linked to acute myeloid leukemia.