TNFSF10 and neoplasm: In addition to their direct cytotoxic functions, NK cells can execute antibody-dependent cell-mediated cytotoxicity (ADCC) through the membrane receptor CD16 (75), inducing tumor cell apoptosis pathways via Fas ligands (FasL) or TNF-related apoptosis-inducing ligands (TRAIL) (76, 77) (Figure 1b).