Parallel developments in serum biomarkers, including PT, INR, APTT (10), C-reactive protein (11) and other serological have shown potential for risk stratification, Sharif demonstrated that low serum albumin (SA) concentration (≤20 g/L) on day 2 of NEC diagnosis is a significant predictor of surgical intervention in neonates with Bell's stage 2 NEC. This evidence concerns the gene ALB and necrotizing enterocolitis.