Four years post operation, she was again diagnosed with three HCC tumor recurrences seen on CT scan (unidimensional at 5.4 cm, 3.7 cm, and <1.0 cm at segments 4-5, segment 5, and segment 7, respectively), with concurrent serum alpha-fetoprotein (AFP) level of 45,598 ng/mL. This evidence concerns the gene AFP and hepatocellular carcinoma.