Various studies have discussed the pathogenesis of hypoglycemia-induced brain injury, which includes a combination of vascular disease, oxidative stress secondary to activation of neuronal nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, neuroinflammation, mitochondrial dysfunction, as well as acetylcholinesterase (AChE) activation with accumulation of amyloid β and tau phosphorylation [12]. Here, ACHE is linked to Hypoglycemia.