MLL is also involved in various biological processes, including embryonic development, cell differentiation, and immune responses.[43] However, in leukemia and other types of cancer, aberrations, such as gene rearrangements, often lead to dysregulated transcriptional control, promoting tumorigenesis [44] To determine whether MLL function was influenced by ASH2L lactylation, we performed CUT&Tag analysis of MLL in various cell lines. This evidence concerns the gene ASH2L and leukemia.