MYC and hepatocellular carcinoma: Key oncogenic signaling pathways, such as transforming growth factor beta, WNT, mammalian target of rapamycin, Hedgehog, angiogenesis, and MYC targets, were significantly upregulated in the primary and metastatic lesions, suggesting the potential role of protein lactylation in promoting HCC progression and distant metastasis (Figure S1A, Supporting Information).