When tumors from control condition reached 35 mm3, mice were treated with 3 mg.kg−1 MPCi, 7ACC2, and the tumor volume was followed over time; we had previously shown using CEST‐MRI with iopamidol as a pHe probe that MPC inhibition significantly reduces tumor pHe.[37] Independently of the diet, the silencing of ACOX1 drastically affected tumor development (Figure 6A), supporting a major role of ACOX1 in growing tumors. This evidence concerns the gene ACOX1 and neoplasm.