This extends beyond our previous work, where we demonstrated that PUFA supplementation can exploit the altered lipid metabolism of acid‐exposed cancer cells to induce ferroptosis.[26] Indeed, we showed that inhibition of lipid droplet (LD) formation (using diacylglycerol acyltransferase (DGAT) inhibitors) was necessary for this strategy to be effective at PUFA concentrations likely achievable in tumors. This evidence concerns the gene DGAT1 and cancer.