Notably, some cases of EMPD had immune profiles (CD8 T cell signature: PDCD1 [PD-1] mRNA, CD274 [PD-ligand 1, PD-L1] mRNA) equivalent to TNBC, suggesting that anti-PD-1 therapies may be effective in some patients with EMPD (Figure 2F, G). This evidence concerns the gene CD8A and extramammary Paget disease.