MAPT and Alzheimer disease: Different αSyn strainsdisplay unique seeding patterns and pathological effects, profoundlyinfluencing the progression and heterogeneity of synucleinopathies.,, Emerging evidence indicates thatthe distribution pattern of LBs in AD patients differs dramaticallyfrom that of PD patients, with LBs identified mainly in the limbicand olfactory regions but less in the substantia nigra and brainstem.−, ,  These findings further support the idea that different αSynstrains might be involved in the co-occurrence of Tau and αSynpathology.