POMC and neoplasm: In addition to adrenal hyperplasia, postoperative pathology has shown adrenal cortical adenomas[13] and adrenal myelolipomas.[14] However, in patients with 17OHD who did not undergo surgery, follow-up revealed that their adrenal masses gradually shrank after dexamethasone treatment, indicating that high levels of adrenocorticotropic hormone likely contribute to secondary tumor formation on the basis of adrenal cortical hyperplasia.[15] Therefore, clinicians should carefully consider adrenal mass surgery only after confirming a 17OHD diagnosis.