Earlier research found that U-STAT3 combined with CRE-binding protein binds on the JunB promoter[50] and combined with c-Jun on the α2-macrogloblin acute-phase response factor element.[65] Other investigations show that Jun activation domain-binding protein 1 (JAB1) interacted with U-STAT3 as a direct binding partner in human colon cancer cell line COLO205, and JAB1 positively regulates U-STAT3 DNA-binding activity through protein–protein interaction. Here, COPS5 is linked to malignant colon neoplasm.