In human glioblastoma, the correlation of U-STAT3 with worse prognosis suggests that U-STAT 3 can be used clinically used as a prognostic marker for glioblastoma treatment.[58] Most investigations have shown a positive correlation between high expression of U-STAT3 and tumor progression, whereas in lung cancer, U-STAT3 has a function in promoting heterochromatin formation, suppressing cell proliferation in vitro, and suppressing tumor growth in vivo,[88,89] it suggests the multiple functions of U-STAT 3 and the complexity in tumor regulation. This evidence concerns the gene STAT3 and neoplasm.