Additionally, the AKT1 gene polymorphism rs1130214 has been linked to antidepressant response in patients with depression.[26] Elevated levels of interleukin-6 are associated with an increased risk of schizophrenia in offspring.[27] The close relationship among these factors in the onset and progression of schizophrenia still requires experimental verification. The gene discussed is IL6; the disease is depressive symptom measurement.