These properties provide strong evidence for the therapeutic potential of nobiletin in the treatment of Alzheimer’s disease.[22] Baicalin inhibits acetylcholine (ACh) or ciclopirox (CPA)-induced endothelial/nitric oxide-dependent relaxation.[23] Licochalcone A possesses neuroprotective effects by acting as a PTP1B inhibitor, enhancing cognitive function through the BDNF-TrkB pathway. This evidence concerns the gene BDNF and early-onset autosomal dominant Alzheimer disease.