In DIC, factor XIII activity is often markedly decreased[5,6] and haptoglobin shows variable behavior ranging from mildly decreased to increased.[6] On the other hand, while thrombotic microangiopathy (TMA) is categorized as a thrombosis with thrombocytopenia syndrome like DIC and causes consumptive thrombocytopenia due to systemic and persistent platelet activation, factor XIII activity is normal, but haptoglobin is significantly decreased. The gene discussed is HP; the disease is deep vein thrombosis.