On immunohistochemistry, lipoleiomyomas were positive for smooth muscle actin, desmin, and vimentin, but negative for HMB45 and CD34.[7] Mignogna et al also reported the immunoreactivity of adipocytes to vimentin, desmin, and SMA, which supports the hypothesis that smooth muscle cells are directly converted into adipocytes.[8]. The gene discussed is DES; the disease is myofibroma.