Using various analytical methods, we identified the genomic and functional networks and pathways associated with the expression of CD318 and its involvement in the immune microenvironment in various cancers such as colorectal adenocarcinoma (COAD), cervical squamous cell carcinoma (CESC), lung adenocarcinoma (LUAD), and pancreatic adenocarcinoma (PAAD). Here, CDCP1 is linked to colorectal adenocarcinoma.