Search terms included “immunotherapy in uveal melanoma”, “intraocular melanoma”, “melanoma of the uvea”, “eye melanoma”, and “choroidal melanoma.” We included only clinical studies involving human mUM patients of any age and sex treated with ICIs (anti-CTLA-4, anti-PD-1, anti-PD-L1) or tebentafusp. This evidence concerns the gene CD274 and uveal melanoma.