The advantage of this study’s strategy was that both VEGF concentrations—low and high—were taken into account and correlated with SLE characteristics, showing their practical significance: higher levels were related to higher atherosclerotic and CVD risks, while lower levels indicated decreased SLE activity via reduced risks of clinical, immunological, and inflammatory variable coexistence related to disease activity and flare. Here, VEGFA is linked to systemic lupus erythematosus.