A comparison of SLE patients with and without renal involvement, defined as proteinuria of ≥0.5 g/day or an eGFR of <50%, showed no differences regarding VEGF concentrations; however, in patients with decreased VEGF serum levels, there was a trend toward a reduced risk of lupus nephritis development (p = 0.056). The gene discussed is VEGFA; the disease is systemic lupus erythematosus.