Moreover, ADAM15, CEA, CA 19-9, and CRP levels were higher in the sera of patients with the presence of lymph node metastasis (N1 subgroup) than in subjects without nodal involvement (N0 subjects); however, statistically significant differences were found only for CEA (p = 0.012) and CRP (p = 0.006) levels (Table 4). This evidence concerns the gene ADAM15 and metastatic malignant neoplasm in the lymph nodes.