AKT1 and cancer: Previously demonstrated to be a regulator in different subtypes of cancer, the research extended the roles of lncRNA MEG3 to psoriasis pathogenesis and showed, using qRT-PCR and Western blot assays, that it suppressed inflammatory responses and facilitated autophagy via the inhibition of the PI3K/AKT/mTOR pathway in TNF-α-treated human keratinocytes and mouse psoriasis models [22].