Auxiliary anti-proliferative activity in cSCC was attributed to the long intergenic non-protein-coding RNA 520 (LINC00520); studies show that LINC00520 mediated the inhibition of EGFR and further suppression of the PI3K/AKT signaling pathway and prevented tumoral progression, invasion, and migration of cSCC cells [52]. This evidence concerns the gene AKT1 and skin squamous cell carcinoma.