EGFR and skin squamous cell carcinoma: MALAT-1 has been proven to be a highly expressed lncRNA in many solid tumors; Zhang et al. explored its role in cSCC tumorigenesis, with qRT-PCR detection in cSCC cell lines demonstrating that MALAT-1 knockdown reduced cellular proliferation, migration, and increased apoptosis in relation to EGFR and the activation of MAPK and PI3K pathways; the authors reported elevated expression of MALAT-1 in relation to UVB stimulation [56].