Patients with diabetes, anaemia, NYHA class II to IV, LVEF between 41% and 49%, poor adherence, HFH in the previous 28 days, eGFR < 30 mL/min/1.73 m2, high NT-proBNP and high furosemide dose were associated with significantly worse QoL (Figure 2). The gene discussed is NPPB; the disease is anemia (phenotype).