While the high degree of infiltration of macrophages in the tumor stroma has been previously correlated to be a poor patient prognosis [46,47], whether or not information derived from PET and SPECT images using CSF-1R and CCR2 targeting ligands can provide independent additional prognostic information in addition to already well-established prognostic markers remains to be proven. This evidence concerns the gene CSF1R and neoplasm.