Clinically, this is relevant because it means that in women with dense breasts (ACR C or D), lesions that manifest with microcalcifications (such as some DCIS or HER2-overexpressing tumors) may still be detected by mammography, whereas noncalcified masses are more likely to be missed in dense tissue. The gene discussed is ERBB2; the disease is ductal breast carcinoma in situ.