A cross-sectional study was carried out at the National Institutes of Health, involving a comparison of individuals with congenital generalized lipodystrophy (CGL, n = 23), complete insulin receptor deficiency (INSR−/−, n = 13), partial deficiency (INSR+/−, n = 17), and type B insulin resistance (TBIR, n = 8). This evidence concerns the gene INSR and insulin-resistance syndrome type B.