The relevant literature was identified through a targeted search of PubMed and Google Scholar (2000–2024) using combinations of terms such as “recombinant TSH,” “thyroid hormone withdrawal,” “RAI therapy,” and “differentiated thyroid cancer.” Preference was given to randomized controlled trials, meta-analyses, large retrospective studies, and major clinical guidelines (e.g., from the American Thyroid Association). The gene discussed is TG; the disease is thyroid cancer.