Bivariate analysis identified prior TB exposure (OR 4.19, 95% CI 1.79–9.78, p < 0.001); prior anti-TNF-α use (OR 1.40, 95% CI 1.00–1.97, p = 0.038) associated with LTBI; and RA (OR 0.38, 95% CI 0.022–0.65, p < 0.001) as a lower frequency of positive QFT Gold Plus. The gene discussed is TNF; the disease is rheumatoid arthritis.