The causes of hyperglycemia in AP include pancreatic islet cell damage due to inflammation and necrosis of the pancreas, insulin resistance induced by pro-inflammatory cytokines and stress hormones, excessive counter-regulatory hormones, exocrine–endocrine crosstalk, etc. Of these, stress plays a significant role in the induction of hyperglycemia. The gene discussed is INS; the disease is alkaline phosphatase measurement.