IFNG and type 1 diabetes mellitus: This “in vitro” and “in vivo” evidence supported the pathogenetic concept that beta-cell destruction in T1DM may be mediated by the Thelper 1 (Th1) subset of T cells producing the proinflammatory cytokines IL-2 and IFN-gamma and counteracted by Th2 cells that produce anti-inflammatory cytokines such as IL-4, IL-10, and IL-13.