P3H2 and myopia: Additionally, P3H3 interacts with basement membrane collagen (IV), which is predominantly expressed at the retinal internal limiting membrane (ILM), the main basement membrane in the eye; therefore, a mutation in the LEPREL1 gene can compromise ILM integrity by disrupting the recognition and hydroxylation of collagen IV at the ILM during eye development, which may lead to an increase in the axial length of the eye and the development of pathological myopia [65,66,67].