APOE and Alzheimer disease: Figure 3 shows strong correlations between CSF SERPINE1 protein levels and pTau181 and tTau, especially in females and APOE4-negative subjects (see also Figure S2 for ADNI results). These results are consistent with the tangles/SERPINE1 association described earlier in fully established AD cases. Note that for Aβ, the expected negative correlation with SERPINE1 was not established (Figure 3A and Figure S2A).