Figure 3 shows strong correlations between CSF SERPINE1 protein levels and pTau181 and tTau, especially in females and APOE4-negative subjects (see also Figure S2 for ADNI results). These results are consistent with the tangles/SERPINE1 association described earlier in fully established AD cases. Note that for Aβ, the expected negative correlation with SERPINE1 was not established (Figure 3A and Figure S2A). Here, SERPINE1 is linked to Alzheimer disease.