MYH14 and hypertrophic cardiomyopathy: In hypertrophic cardiomyopathy (HCM), myosin mutations that enhance cross-bridge formation activate mechanosensitive complexes centered around MLP (muscle LIM protein), leading to Z-disc destabilization, the disinhibition of the calcineurin–NFAT signaling pathway, and pathological hypertrophic remodeling [153].