The frequencies of the PNPLA3 GG and CG + GG genotypes were significantly lower in healthy controls compared to the MASLD-HCC group (OR 0.36; 95% CI 0.19–0.66; p < 0.001, and OR 0.59; 95% CI 0.39–0.91; p = 0.009, respectively), but their frequencies did not significantly differ from the VIRAL-HCC group. The gene discussed is PNPLA3; the disease is hepatocellular carcinoma.