The remaining minority may possess cryptic rearrangements, such as NUP98::NSD1 gene fusions, or nucleotide-level mutations, such as in NPM1, FLT3 internal tandem duplication (-ITD), or biallelic mutations in CEBPA. Indeed, there is an inverse relationship between age and the presence of visually identifiable translocations in all of AML. This evidence concerns the gene NPM1 and acute myeloid leukemia.