The remaining minority may possess cryptic rearrangements, such as NUP98::NSD1 gene fusions, or nucleotide-level mutations, such as in NPM1, FLT3 internal tandem duplication (-ITD), or biallelic mutations in CEBPA. Indeed, there is an inverse relationship between age and the presence of visually identifiable translocations in all of AML. The gene discussed is FLT3; the disease is acute myeloid leukemia.