Regarding the gene in which the familial genetic variants were located, the major perception of the risk of developing a tumor by the family members, and the effective information transfer by the index case, 66 and 26 familial pathogenic variants were located in the BRCA1 and BRCA2 genes (corresponding to 56% and 22% of the total), respectively, 6 PVs were in the TP53 gene (5%), and 20 were in other genes (5 in the MSH6 gene, 4 in the ATM gene, 2 in the CHEK2, MLH1, and MSH2 genes, and finally 1 in the PALB2, APC, RAD51C, BRIP1, and MITF genes) (Figure 1C). The gene discussed is CHEK2; the disease is neoplasm.