Furthermore, based on the dysregulated expression of genes involved in protein degradation, such as Ubiquitin Protein Ligase E3C (UBE3C), OTU Deubiquitinase 4 (OTUD4), and Proteasome 26S Subunit, Non-ATPase 7 (PSMD7), impaired proteostasis could be a contributing factor to granulosa cell dysfunction and follicular cyst formation. The gene discussed is OTUD4; the disease is Follicular Cyst.