Therefore, this study aims to investigate, for the first time, the allele, genotype, and haplotype distribution and association of the −625 G>C (rs8073069), −241 C>T (rs17878467), and −31G>C (rs9904341) variants in the BIRC5 gene with breast cancer in Mexican women, as well as their clinicopathological characteristics. This evidence concerns the gene BIRC5 and breast cancer.