ITK and obesity due to melanocortin 4 receptor deficiency: As shown in Figure 5C–E, in obese patients, SPP1 was significantly upregulated in B cells, lymphatic endothelial cells, macrophages, neutrophils, NK cells and T cells of the obesity group, while ITK and CCL5 genes were only significantly upregulated in NK cells of obesity group, which was consistent with the previous analysis results.