For instance, in pediatric acute myeloid leukaemias (AML) carrying the recurrent t(7;12)(q36;p13) translocation, the MNX1 gene (formerly HLXB9) is repositioned within the nucleus and aberrantly expressed, demonstrating how changes in 3D genomic localization—not just gene disruption or fusion—can misregulate transcription by disrupting the regulatory element [5,24]. Here, MNX1 is linked to acute myeloid leukemia.