ATP1A1 and adenoma: Search terms included combinations of Medical Subject Headings (MeSH) and free-text keywords such as “aldosterone-producing adenoma”, “APA”, “primary aldosteronism”, “somatic mutation”, “human”, and names of individual genes reported in the literature, such as KCNJ5, ATP1A1, ATP2B3, SLC30A1, CACNA1D, CACNA1H, CTNNB1, GNA11/Q, CADM1, and PRKACA. Included studies comprised original research articles reporting somatic mutations in human APA samples, functional characterization studies, and investigations linking mutation status to clinical phenotypes or outcomes.