Search terms included combinations of Medical Subject Headings (MeSH) and free-text keywords such as “aldosterone-producing adenoma”, “APA”, “primary aldosteronism”, “somatic mutation”, “human”, and names of individual genes reported in the literature, such as KCNJ5, ATP1A1, ATP2B3, SLC30A1, CACNA1D, CACNA1H, CTNNB1, GNA11/Q, CADM1, and PRKACA. Included studies comprised original research articles reporting somatic mutations in human APA samples, functional characterization studies, and investigations linking mutation status to clinical phenotypes or outcomes. This evidence concerns the gene CACNA1H and primary aldosteronism.