EGFR and neoplasm: Adenocarcinomas of the lung can be categorized as oncogene-addicted (targetable oncogenes drive tumor progression) or non-oncogene-addicted, with the EGFR tyrosine kinase receptor being the second most common targetable mutation and the third most frequently mutated gene overall (TP53 50–60%, KRAS 25–30%), detected in approximately 10–20% of Caucasian patients and up to 50% of Asian patients.