DLA class II haplotypes have been associated with an increased risk of primary hypoadrenocorticism and symmetrical lupoid onychodystrophy in Border Collies [2], as well as with diabetes mellitus in Samoyeds, Tibetan Terriers, and Cairn Terriers [36], whereas polymorphisms in the TLR4 and TLR5 genes have been linked to inflammatory bowel disease in German Sheperd dogs [19]. This evidence concerns the gene TLR4 and inflammatory bowel disease.