Several orthologs enriched in the SLE-F group—including K08191 (methyl-accepting chemotaxis protein), K10118 (ABC transporter for oligosaccharides), and K02429 (L-fucose permease)—highlight a gene-level shift toward microbial functions associated with mucosal sensing, nutrient utilization, and host interaction. Here, ABCG2 is linked to systemic lupus erythematosus.