ABCG2 and systemic lupus erythematosus: Notably, SLE-F treatment promoted the enrichment of microbial orthologs involved in nutrient transport (e.g., ABC transporters), host-glycan metabolism (e.g., L-fucose permease), and protein homeostasis (e.g., peptidyl-prolyl isomerase), while suppressing genes linked to dysbiosis and pathogenicity (e.g., glycosyltransferases, DnaC replication initiator).